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The Comparative Neuromuscular Laboratory will be closed Friday, July 3, 2015, in observance of the Independence Day holiday. To ensure sample delivery prior to the holiday closure, we request that tissue (muscle and nerve biopsies) be shipped by an overnight service no later than Wednesday, July 1, 2015. Shipment of serum samples is fine over this period. Shipment of tissue samples can resume on Monday, July 6, 2015.

Please note important changes to sample submission procedures for the Comparative Neuromuscular Laboratory and the Biochemical Genetics Laboratory.

Welcome to the Comparative Neuromuscular Laboratory located in the School of Medicine at the University of California, San Diego. This laboratory, established in 1990, is an international reference center dedicated to the diagnosis and study of spontaneous neuromuscular diseases in companion animals. The laboratory is directed by G. Diane Shelton DVM, PhD, DACVIM (Internal Medicine) and Professor in the Department of Pathology.  Dr. Shelton is a recognized specialist in comparative neuromuscular diseases with over 190 publications relevant to both human and veterinary medicine (PubMed; Shelton GD ).  Specialized testing performed in this laboratory includes evaluation of muscle and peripheral nerve biopsies by State-of-the-Art methods, immunohistochemistry and immunoblotting for the diagnosis of various muscular dystrophies and other congenital myopathies, and testing  for acetycholine  receptor antibodies for the diagnosis of canine and feline myasthenia  gravis. Metabolic testing for inborn errors is performed in collaboration with the Biochemical Genetics Laboratory at UCSD. The faculty and staff of the Comparative Neuromuscular  Laboratory hope that this website provides valuable information  to clinicians, researchers, pet owners and anyone interested in comparative neuromuscular diseases.