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Welcome to the Comparative Neuromuscular Laboratory located in the School of Medicine at the University of California, San Diego. This laboratory, established in 1990, is an international reference center dedicated to the diagnosis and study of spontaneous neuromuscular diseases in companion animals. The laboratory is directed by G. Diane Shelton DVM, PhD, DACVIM (Internal Medicine) and Professor in the Department of Pathology. Dr. Shelton is a recognized specialist in comparative neuromuscular diseases with over 190 publications relevant to both human and veterinary medicine (PubMed; Shelton GD ). Specialized testing performed in this laboratory includes evaluation of muscle and peripheral nerve biopsies by State-of-the-Art methods, immunohistochemistry and immunoblotting for the diagnosis of various muscular dystrophies and other congenital myopathies, and testing for acetycholine receptor antibodies for the diagnosis of canine and feline myasthenia gravis. Metabolic testing for inborn errors is performed in collaboration with the Biochemical Genetics Laboratory at UCSD. The faculty and staff of the Comparative Neuromuscular Laboratory hope that this website provides valuable information to clinicians, researchers, pet owners and anyone interested in comparative neuromuscular diseases.