Comparative Neuromuscular Laboratory

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Dr. Diane Shelton

  • G. Diane Shelton DVM, PhD, DACVIM (Internal Medicine) is a Professor in the Department of Pathology, School of Medicine, University of California, San Diego and director of the Comparative Neuromuscular Laboratory. Dr. Shelton is a graduate of the University of California, Davis School of Veterinary Medicine , completed an internship at Michigan State University and a residency in Small Animal Medicine at the University of Pennsylvania.
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  • Recent Publications from the Comparative Neuromuscular Laboratory

  • Sarcoglycan A mutation in miniature dachshund dogs causes limb-girdle muscular dystrophy 2D
    In: Skeletal Muscle. 2021 Jan 7;11(1):2.

  • Pathogenic variants in COL6A3 cause Ullrich-like congenital muscular dystrophy in young Labrador retriever dogs
    In: Neuromuscular Disorders 2020 May;30(5):360-367.

  • A mutation in the mitochondrial aspartate/glutamate carrier leads to a more oxidizing intramitochondrial environment and an inflammatory myopathy in Dutch shepherd dogs
    In: Journal of Neuromuscular Diseases 2019;6(4):485-501.

About the Laboratory

  • Welcome to the Comparative Neuromuscular Laboratory located in the School of Medicine at the University of California, San Diego. This laboratory, established in 1990, is an international reference center dedicated to the diagnosis and study of spontaneous neuromuscular diseases in companion animals. Specialized testing performed in this laboratory includes evaluation of muscle and peripheral nerve biopsies by state-of-the-art methods, immunohistochemistry, immunofluorescence staining and immunoblotting for the diagnosis of various muscular dystrophies and other congenital myopathies. Read More »






  • Muscular dystrophy-dystrolycanopathy in a family of Labrador retrievers with a LARGE1 mutation

    In: Neuromuscular Disorders In Press: Available online 28 July 2021
  • Congenital myasthenic syndrome in Golden retrievers is associated with a novel COLQ mutation
    In: Journal of Veterinary Internal Medicine 2020;34(1):258-265.
  • Polyneuropathy in young Siberian Huskies caused by degenerative and inflammatory diseases
    In: Veterinary Pathology 2020;57(5):666-674.

News and Updates

Important information

In light of the declaration of a National Emergency due to the COVID-19 outbreak, the Comparative Neuromuscular Laboratory is taking measures to balance the need to protect the health of laboratory personnel while attempting to continue laboratory operations to the extent possible. During this time, the turnaround time for testing and response time to emails and voicemails may be longer than under normal operations. We ask for your patience and understanding during this time and should you have questions or concerns, please email our laboratory at musclelab@ucsd.edu.

2021 Submission forms

Please note that beginning January 1, 2021, the Comparative Neuromuscular Laboratory will be increasing the price of all tests. The 2021 sample submission form and instruction sheet is now available for download.

Closure dates

Christmas and New Years Closure Dates
The laboratory will be closed Thursday, December 23, 2021, through Sunday, January 2, 2022. We will reopen on Monday, January 3, 2022.

Due to the holiday schedule and campus building closures, we request that no tissue samples (muscle and nerve biopsies) be submitted between December 20, 2021 and December 31, 2021. Shipment of serum samples via an overnight service can proceed until December 21, 2021. To ensure serum sample viability during the laboratory closure, please keep the samples refrigerated and only ship samples once the laboratory has reopened. Shipment of tissue and serum samples can resume on Monday, January 3, 2022. Should you have any questions or concerns, please feel free to contact our laboratory (musclelab@ucsd.edu or 858-534-1537). 

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