Comparative Neuromuscular Laboratory

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Dr. Diane Shelton

  • Diane Shelton, D.V.M, PhD, DACVIM, is a graduate of the UC Davis School of Veterinary Medicine, completed an internship in small animal medicine and surgery at Michigan State University and a residency in small animal internal medicine at the University of Pennsylvania. She completed a PhD in Comparative Pathology at UC Davis followed by a post-doctoral fellowship at the Salk Institute for Biological Studies, La Jolla, CA in the laboratory of Dr. Jon Lindstrom, with an emphasis on experimental and naturally occurring models of myasthenia gravis. In 1990, Dr. Shelton established the Comparative Neuromuscular Laboratory (CNL) in the School of Medicine, UC San Diego, an international reference center for the study of spontaneously occurring neuromuscular diseases in companion animals. Currently she is Director of the CNL and Professor, Department of Pathology at UCSD.

  • Recent Publications from the Comparative Neuromuscular Laboratory

  • Sarcoglycan A mutation in miniature dachshund dogs causes limb-girdle muscular dystrophy 2D
    In: Skeletal Muscle. 2021 Jan 7;11(1):2.

  • Pathogenic variants in COL6A3 cause Ullrich-like congenital muscular dystrophy in young Labrador retriever dogs
    In: Neuromuscular Disorders 2020 May;30(5):360-367.

  • Tandem duplication within the DMD gene in Labrador Retrievers with a mild clinical phenotype
    In: Neuromuscular Disorders 2022;32(10) 836-841.

About the Laboratory

  • Welcome to the Comparative Neuromuscular Laboratory located in the School of Medicine at the University of California, San Diego. This laboratory, established in 1990, is an international reference center dedicated to the diagnosis and study of spontaneous neuromuscular diseases in companion animals. Specialized testing performed in this laboratory includes evaluation of muscle and peripheral nerve biopsies by state-of-the-art methods, immunohistochemistry, immunofluorescence staining and immunoblotting for the diagnosis of various muscular dystrophies and other congenital myopathies. Read More »

  • A mutation in the mitochondrial aspartate/glutamate carrier leads to a more oxidizing intramitochondrial environment and an inflammatory myopathy in Dutch shepherd dogs

    In: Journal of Neuromuscular Diseases 2019;6(4):485-501

    Muscular dystrophy-dystrolycanopathy in a family of Labrador retrievers with a LARGE1 mutation
    In: Neuromuscular Disorders 2021 31(11) 1169-1178

  • Congenital myasthenic syndrome in Golden retrievers is associated with a novel COLQ mutation
    In: Journal of Veterinary Internal Medicine 2020;34(1):258-265.
  • Polyneuropathy in young Siberian Huskies caused by degenerative and inflammatory diseases
    In: Veterinary Pathology 2020;57(5):666-674.

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News and Updates

Important information

We may periodically experience short delays due to Covid related staff illness and supply chain shortages. Please have patience as we aim to provide the best services possible.

Due to technical problems and supply chain issues, we will no longer offer plasma lactate and pyruvate testing. These tests are being removed from our submission form. 

2023 Submission forms

Please note that beginning January 1, 2023, the Comparative Neuromuscular Laboratory will be increasing the price of all tests. The 2023 sample submission form and instruction sheet is now available for download.

Closure dates

2023-2024 Holiday Closure Dates
The laboratory will be closed Monday, December 25, 2023, through Tuesday, January 2, 2024. We will reopen on Wednesday, January 3, 2024. Due to the holiday schedule and campus building closures, we request that no tissue samples (muscle and nerve biopsies) be submitted between December 22, 2023, and January 2, 2024. Shipment of serum samples via an overnight service can proceed until December 22, 2023. To ensure serum sample viability during the laboratory closure, please keep the samples refrigerated and only ship samples once the laboratory has reopened. Shipment of tissue and serum samples can resume on Tuesday, January 2, 2024. Should you have any questions or concerns, please feel free to contact our laboratory or (858-534-1537).

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