Comparative Neuromuscular Laboratory

Myasthenia Gravis

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Acquired myasthenia gravis (MG) is a disorder of neuromuscular transmission resulting from autoantibody mediated destruction of the nicotinic acetylcholine receptors at the neuromuscular junction. Acquired MG is the most common neuromuscular disorder that can be diagnosed in dogs. It occurs less commonly in cats. There is a broad spectrum of clinical presentations ranging from focal MG associated with regurgitation due to esophageal dilatation or dysphagia, generalized weakness with or without an associated megaesophagus, MG associated with thymoma, or acute fulminating MG with rapid deterioration of clinical signs over a period of hours. The course of the disease can be variable and unpredictable. Unfortunately, the mortality rate in canine acquired MG is still unacceptably high with approximately 50% of the dogs diagnosed with acquired MG succumbing to aspiration pneumonia or respiratory paralysis. The importance of early recognition of regurgitation (and not vomiting) associated with esophageal dilation, an accurate diagnosis, and appropriate therapy cannot be stressed enough. Below are some of our featured Myastenia Gravis cases

  • Most commonly asked questions about acquired myasthenia gravis
  • Glossary for Myasthenia Gravis
  • Effective treatment regimen for megaesophagus secondary to focal myasthenia gravis
  • "Bailey Chair": Feeding Chair For Dogs With Megaesophagus
  • High Euthanasia Rate in Feline Acquired Myasthenia Gravis
  • Myasthenia gravis and Immune-mediated Polymyositis in a 6 year old Mixed-breed Dog
  • Acquired myasthenia gravis and hypothyroidism in a 5 year old MC mixed breed dog
  • Three autoimmune diseases in an 8 year old female-spayed Labrador retriever mix
  • Genetic Test Now Available for Congenital Myasthenic Syndrome in Young Labrador Retriever Puppies
  • Myasthenia gravis and cranial mediastinal mass in a 14 year-old MC cat